MENTAL HEALTH DISORDERS DUE TO GUT MICROBIOME ALTERATION AND NLRP3 INFLAMMASOME ACTIVATION AFTER SPINAL CORD INJURY: MOLECULAR MECHANISMS, PROMISING TREATMENTS, AND AIDS FROM ARTIFICIAL INTELLIGENCE

Aside from its immediate traumatic effects, spinal cord injury (SCI) presents multiple secondary complications that can be harmful to those who have been affected by SCI.Among these secondary effects, gut dysbiosis (GD) and the activation of the NOD (nucleotide-binding oligomerization domain) like receptor-family pyrin-domain-containing three (NLRP

Step-ratio automatic transmission upshift performance can be improved by modulating the off-going (OFG) clutch during the inertia phase.In this paper, a static powertrain performance model is derived and applied for the purpose of numerically efficient, multi-objective shift control parameter optimization for the inertia phase.The optimization is a

The ultimate goal of any scientific development is to increase well-being and human health.Novel strategies are required for the achievement of safe and effective therapeutic treatments beyond the conventional ones, and society needs new requirements for new technologies, moving towards clean and green technology development.Green nanotechnology is

Abstract Due to the small size and biocompatibility of molecules, molecular logic-based computation is a gateway to the informational basis of life processes.Logic-based computation operates widely with discrete molecules of up to nanometric sizes.The contribution of molecule-based bulk materials of milli/centimetric size to the field has begun in

OBJECTIVES/SPECIFIC AIMS: Opioid use disorder (OUD) is a national epidemic and identified as a top priority by the practices and communities in rural Colorado.Until recently, few resources existed to address OUD in rural communities.In addition to training primary care and behavioral health practice teams in medication assisted treatment (MAT), Imp